Cytokine Regulation of Inflammatory Pain

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon

2020-03-11

The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent yea..

GM-CSF– and IRF4-dependent signaling can regulate myeloid cell numbers and the macrophage phenotype during inflammation

MC Lee, DC Lacey, AJ Fleetwood, A Achuthan, JA Hamilton, AD Cook

2019-05-15

Studies have demonstrated the importance of a GM-CSF→IFN regulatory factor 4 (IRF4)→CCL17 pathway, first identified in monocytes/m..

CSF-1 in inflammatory and arthritic pain development

R Saleh, MC Lee, SH Khiew, C Louis, AJ Fleetwood, A Achuthan, I Förster, AD Cook, JA Hamilton

2018-10-01

Pain is one of the most debilitating symptoms in many diseases for which there is inadequate management and understanding. CSF-1, ..

Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages

AT Hsu, TJ Lupancu, MC Lee, AJ Fleetwood, AD Cook, JA Hamilton, A Achuthan

2018-07-20

Interleukin 4 (IL4) is generally viewed as a Th2 cytokine capable of polarizing macrophages into an anti-inflammatory phenotype, w..

CCL17 blockade as a therapy for osteoarthritis pain and disease

MC Lee, R Saleh, A Achuthan, AJ Fleetwood, I Förster, JA Hamilton, AD Cook

2018-04-05

Background: Granulocyte macrophage-colony stimulating factor (GM-CSF) has been implicated in the pathogenesis of a number of infla..

TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17

AD Cook, MC Lee, R Saleh, HW Khiew, AD Christensen, A Achuthan, AJ Fleetwood, DC Lacey, JE Smith, I Förster, JA Hamilton

2018-03-22

TNF and granulocyte macrophage-colony stimulating factor (GM-CSF) have proinflammatory activity and both contribute, for example, ..

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article

A Achuthan, ASM Aslam, Q Nguyen, PY Lam, AJ Fleetwood, AT Frye, C Louis, MC Lee, JE Smith, AD Cook, M Olshansky, SJ Turner, JA Hamilton

2018-03-01

Glucocorticoids (GCs) are potent anti-inflammatory drugs whose mode of action is complex and still debatable. One likely cellular ..

Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation

A Achuthan, AD Cook, MC Lee, R Saleh, HW Khiew, MWN Chang, C Louis, AJ Fleetwood, DC Lacey, AD Christensen, AT Frye, PY Lam, H Kusano, K Nomura, N Steiner, I Förster, SL Nutt, M Olshansky, SJ Turner, JA Hamilton

2016-09-01

Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GMCSF) can fun..